Comparative analysis of infection and transformation of lymphocytes from African buffalo and Boran cattle with Theileria parva subsp. parva and T. parva subsp. lawrencei

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Chemotherapy of Theileria parva lawrencei infections in cattle with halofuginone.

Halofuginone lactate, given once orally at a dosage rate of 1,2 mg/kg body mass on the 1st, 3rd or 5th days of fever, resulted in the recovery of only 1 out of 5 splenectomized cattle. Three splenectomized animals, treated on the 1st as well as the 4th day of fever, recovered and were then carriers. Six untreated controls all died. The potential value of a chemotherapeutic agent for Theileria p...

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Theileria parva infection induces autocrine growth of bovine lymphocytes.

Bovine lymphocytes infected with the parasite Theileria parva continuously secrete a growth factor that is essential for their proliferation in vitro and also constitutively express interleukin 2 receptors on their surface. Dilution of the secreted growth factor, caused by culturing cells at low density, results in retardation of culture growth. Human recombinant interleukin 2, however, effecti...

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Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva

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East Coast fever caused by Theileria parva parva has been eradicated from South Africa, but tick-borne infections with other species of Theileria still occur, particularly in cattle and African buffalo (Syncerus caffer). One such infection is Corridor disease caused by T. parva lawrencei, which is controlled by restricting the movement of African buffalo. Other species reviewed are T. parva bov...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1986

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.53.1.186-191.1986